Client:  DSM Pharmaceuticals - Greenville, NC 

Project: Processing Modifications for DEA-Controlled Substance

Scope: Design facility modifications required for installation of concrete UL- listed Class M/DEA-approved modular vault, DEA-controlled processing areas and packaging line.

• Vault incorporated into existing warehouse
• Rooms retrofitted for Containment and Reconciliation of Dust
• Incorporate Post Lifts to handle 100 cu. ft. Bulk Containers
• Packaging Line Upgrades with Dust Collection System

Client:  EISAI, INC. - Research Triangle Park, NC  

Project: Oral Solid Dosage Manufacturing Expansion

Construction Cost: $8 MM

Project was integrated into middle of active manufacturing operation without need for major shutdown.

Scope: Convert empty building space into oral solid dosage suite housing fluid bed dryers, granulators, blenders, coaters, and lifts.

• Fluid Bed Process and Coating Equipment Ducting Systems designed for Explosion Isolation and Dust Collection
• Purified Water, Solvent, and Nitrogen Systems Installation
• Walls designed for High Purity Water Wash-down
• Closed, Solvent-based Coating Solution Preparation System
• Space Programming and Process Flow Diagram Development

Client:  Pharmacore - High Point, NC  

Project: GMP Pilot Plant

Construction Cost:$ 10 MM

Scope: Expansion of production facility to allow for API (Active Pharmaceutical Ingredient) manufacturing operations, following cGMP guidelines. The Process Room was designed to facilitate production, product, and personnel flow. The production area was designed as an H-2 rating to allow dispensing and use of flammable liquids. A new process control platform to monitor and control all critical aspects of the production process. Quality control, analytical, and production laboratories were included in the design.

HIPP was involved in the conceptual, preliminary, and detailed design effort..

• Building converted from business to high hazard capacity
• Pilot plant designed for multiple products
• Cryogenic and high temperature processes
• Hydrogenation processes
• Explosion prevention techniques in lie of deflagration venting
• Waste neutralization with surge tank
• Firewater and spill containment
• Small molecule reactor processes